Important Questions/Topics from UHS Past Papers of Biochemistry First Professional Part II (Second Year MBBS)
Credits: All medical 2010 batch (Member: Hasaan Shahid)
1) Chemiosmotic Hypothesis.
2) Draw Electron Transport Chain along with its various inhibitors.
3) Enumerate uncouplers of oxidative phosphorylation with their mechanism of action.
4) What is oxidative phosphorylation?
5) Gluconeogenesis - convert pyruvate and glycerol into glucose.
6) Name glycogen storage diseases.
7) Glycogenolysis.
8) Galactosemia.
9) Wernicke-Korsakoff's syndrome.
10) Discuss fate of ammonia? What are its sources?
11) Catabolism of sulphur containing amino acids.
12) Role of homocystein in heart disease.
13) What are the disorders during breakdown of phenylalanine. What is the fate of phenylalanine?
14) Mechanism of fat digestion. How are they transported to system circulation after absorption from GIT?
15) HMP Pathway and in which sites does it occur?
16) Functions of cholesterol and bile salts.
17) How purines are regulated?
18) Breakdown and synthesis of pyramidines?
19) How uric acid is synthesized from its immediate precursors?
20) Protein synthesis steps.
21) Steps in transcription of RNA molecule.
22) Draw DNA molecule structure.
23) Mechanism of action of insulin in lowering blood glucose level.
24) Enumerate hormones of adrenal gland.
25) Metabolic role of glucocorticoids.
26) Synthesis of thyroid hormones. Describe.
27) Draw and label diagram of replication fork and explain.
28) How DNA is organized into chromosomes?
29) Describe importance of proofreading and DNA repair mechanism.
30) What is mutation? Discuss various types of mutations in sickle cell anemia?
31) Discuss types of mutations with examples.
32) Role of antibiotics in translation.
33) Elaborate various steps of transcription in eukaryotes.
34) Discuss the principle of PCR with its application.
35) Describe Down's syndrome. Discuss its genetic basis.
36) Name different acids produced in body. Mention their sources.
37) Role of kidney and respiration in maintaining pH.
38) Metabolism of glycine and serine.
39) Enumerate various biochemical reactions of amino acids in the body. Explain any two.
40) Genetic disorders related to pyramidine metabolism.
41) Color blindness.
42) Sickle cell anemia.
43) Enlist hormones of hypophyseal gland.
44) Write down metabolic effects of cortisol, aldosterone and insulin.
45) Gout, its types and related biochemical reactions.
46) Biochemical parameters of diabetic patients.
47) Rate limiting steps of cholesterol metabolism.
48) Class of medication that acts on the rate limiting step of cholesterol metabolism.
49) Enumerate various inhibitors of respiratory chain with their mechanism of action.
50) Synthesis and breakdown of pyrimidine.
51) How is uric acid formed in the body?
52) What is treatment of gout at different stages?
53) Regulation of purine nucleotides. Draw.
54) Salvage pathway of purine synthesis.
55) Irreversible steps of glycolysis.
56) TCA cycle. Point out committed steps.
57) Fatty acid synthase multienzyme complex.
58) Beta oxidation of fatty acids along with energy calculations.
59) Urea cycle, with regulation and importance. Phenylketonuria.
60) Metabolic effects of insulin on carbohydrate, protein and lipid metabolism.
61) Elaborate effects of parathyroid hormone (PTH).
62) Biosynthesis of cholesterol.
63) Von Gierke's disease with causes and features.
64) Bile salts and how are they secreted.
65) Various phases of digestion of lipids and carbohydrates.
66) How GIT mucosa is protected? Give mechanisms.
67) Hormones of GIT. Role of any two.
68) Peptic ulcer. How is it treated?
69) End product of beta-oxidation. How many acetyl Co A molecules are produced during the beta oxidation of palmitic acid?
70) How odd chain fatty acids are oxidized?
71) How ketone bodies are synthesized?
72) Fatty acid synthesis.
73) Tay Sach's disease.
74) Steps of gluconeogenesis.
75) Metabolism of methionine.
76) Maple syrup urine disease.
77) Deamination and decarboxylation in proteins with examples.
Credits: All medical 2010 batch (Member: Hasaan Shahid)
1) Chemiosmotic Hypothesis.
2) Draw Electron Transport Chain along with its various inhibitors.
3) Enumerate uncouplers of oxidative phosphorylation with their mechanism of action.
4) What is oxidative phosphorylation?
5) Gluconeogenesis - convert pyruvate and glycerol into glucose.
6) Name glycogen storage diseases.
7) Glycogenolysis.
8) Galactosemia.
9) Wernicke-Korsakoff's syndrome.
10) Discuss fate of ammonia? What are its sources?
11) Catabolism of sulphur containing amino acids.
12) Role of homocystein in heart disease.
13) What are the disorders during breakdown of phenylalanine. What is the fate of phenylalanine?
14) Mechanism of fat digestion. How are they transported to system circulation after absorption from GIT?
15) HMP Pathway and in which sites does it occur?
16) Functions of cholesterol and bile salts.
17) How purines are regulated?
18) Breakdown and synthesis of pyramidines?
19) How uric acid is synthesized from its immediate precursors?
20) Protein synthesis steps.
21) Steps in transcription of RNA molecule.
22) Draw DNA molecule structure.
23) Mechanism of action of insulin in lowering blood glucose level.
24) Enumerate hormones of adrenal gland.
25) Metabolic role of glucocorticoids.
26) Synthesis of thyroid hormones. Describe.
27) Draw and label diagram of replication fork and explain.
28) How DNA is organized into chromosomes?
29) Describe importance of proofreading and DNA repair mechanism.
30) What is mutation? Discuss various types of mutations in sickle cell anemia?
31) Discuss types of mutations with examples.
32) Role of antibiotics in translation.
33) Elaborate various steps of transcription in eukaryotes.
34) Discuss the principle of PCR with its application.
35) Describe Down's syndrome. Discuss its genetic basis.
36) Name different acids produced in body. Mention their sources.
37) Role of kidney and respiration in maintaining pH.
38) Metabolism of glycine and serine.
39) Enumerate various biochemical reactions of amino acids in the body. Explain any two.
40) Genetic disorders related to pyramidine metabolism.
41) Color blindness.
42) Sickle cell anemia.
43) Enlist hormones of hypophyseal gland.
44) Write down metabolic effects of cortisol, aldosterone and insulin.
45) Gout, its types and related biochemical reactions.
46) Biochemical parameters of diabetic patients.
47) Rate limiting steps of cholesterol metabolism.
48) Class of medication that acts on the rate limiting step of cholesterol metabolism.
49) Enumerate various inhibitors of respiratory chain with their mechanism of action.
50) Synthesis and breakdown of pyrimidine.
51) How is uric acid formed in the body?
52) What is treatment of gout at different stages?
53) Regulation of purine nucleotides. Draw.
54) Salvage pathway of purine synthesis.
55) Irreversible steps of glycolysis.
56) TCA cycle. Point out committed steps.
57) Fatty acid synthase multienzyme complex.
58) Beta oxidation of fatty acids along with energy calculations.
59) Urea cycle, with regulation and importance. Phenylketonuria.
60) Metabolic effects of insulin on carbohydrate, protein and lipid metabolism.
61) Elaborate effects of parathyroid hormone (PTH).
62) Biosynthesis of cholesterol.
63) Von Gierke's disease with causes and features.
64) Bile salts and how are they secreted.
65) Various phases of digestion of lipids and carbohydrates.
66) How GIT mucosa is protected? Give mechanisms.
67) Hormones of GIT. Role of any two.
68) Peptic ulcer. How is it treated?
69) End product of beta-oxidation. How many acetyl Co A molecules are produced during the beta oxidation of palmitic acid?
70) How odd chain fatty acids are oxidized?
71) How ketone bodies are synthesized?
72) Fatty acid synthesis.
73) Tay Sach's disease.
74) Steps of gluconeogenesis.
75) Metabolism of methionine.
76) Maple syrup urine disease.
77) Deamination and decarboxylation in proteins with examples.
